United States
Cardiac Diagnostics & Monitoring

For Healthcare Professionals


Cryptogenic Stroke

Each year in the United States, 795,000 people suffer a stroke. 610,000 of those strokes are first occurrences and 185,000 are recurrent.1

Fifteen percent of the strokes are hemorrhagic, and 85% are ischemic. Of those ischemic strokes, approximately 30% are cryptogenic (unknown cause).2

Ischemic Stroke Breakdown


The Link between Atrial Fibrillation and Cryptogenic Stroke and the Role of Insertable Cardiac Monitoring

  • Studies indicate that undiagnosed atrial fibrillation is present in patients with cryptogenic stroke that is not detected during routine diagnostic procedures.3
  • Episodes are intermittent and may not be caught during monitoring.4
  • Holter Monitors are often used for cardiac monitoring after a cryptogenic stroke. The yield of three to seven days of ambulatory Holter monitoring after
    cryptogenic stroke is estimated to be 6%.5

Identification of AF changes therapy to OAC, which can prevent a second stroke. OAC offers a 64% relative risk reduction for stroke compared to placebo.6

Reveal® Insertable Cardiac Monitors are designed to help you detect AF in cryptogenic stroke patients through long-term, continuous, automatic ECG monitoring. With Reveal LINQ ICM and Reveal XT ICM, you can monitor patients for up to 3 years.7

Next: Guidelines

  1. Hajat C, Heuschmann PU, Coshall C, Padayachee S, Chambers J, Rudd AG, et al. Incidence of aetiological subtypes of stroke in a multi-ethnic population based study: the South London Stroke Register. J Neurol Neurosurg Psychiatr. 2011;82:527–533.
  2. Liao J, Khalid Z, Scallan C, Morillo C, O’Donnell M. Noninvasive cardiac monitoring for detecting paroxysmal atrial fibrillation or flutter after acute ischemic stroke: a systematic review. Stroke 2007;38:2935–2940.
  3. Cotter, P.E., et al., Incidence of atrial fibrillation detected by implantable loop recorders in unexplained stroke. Neurology, 2013 Apr 23;80(17):1546-50;
  4. Ritter, M.A., et al., Occult Atrial Fibrillation in Cryptogenic Stroke: Detection by 7-Day Electrocardiogram Versus Implantable Cardiac Monitors. Stroke, 2013 May;44(5):1449-52.
  5. Tayal AH, Tian M, Kelly KM, Jones SC, Wright DG, Singh D, et al. Atrial fibrillation detected by mobile cardiac outpatient telemetry in cryptogenic TIA or stroke. Neurology. 2008;71:1696–1701.
  6. Stroke Prevention in Atrial Fibrillation Study. Final results. Circulation. 1991; 84:527-39.
  7. Etgen T, Hochreiter M, Mundel M, Freudenberger T. Insertable cardiac event recorder in detection of atrial fibrillation after cryptogenic stroke: an audit report. Stroke. 2013; 44(7):2007-9.